Han, Huijong, Ph.D.

2023–2024
37	Light-induced Trp_in/Met_out Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC Anaïs Chretien, Marius F. Nagel, Sabine Botha, Raphaël de Wijn, Lea Brings, Katerina Dörner, Huijong Han, Jayanath C. P. Koliyadu, Romain Letrun, Adam Round, Tokushi Sato, Christina Schmidt, Radu-Costin Secareanu, David von Stetten, Mohammad Vakili, Agnieszka Wrona, Richard Bean, Adrian Mancuso, Joachim Schulz, Arwen R. Pearson, Tilman Kottke, Kristina Lorenzen, and Robin Schubert J. Mol. Biol. 436, 168439 (2024) [BibTeX][pdf][abstract]doi:10.1016/j.jmb.2024.168439
36	Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography Mohammad Vakili, Huijong Han, Christina Schmidt, Agnieszka Wrona, Marco Kloos, Iñaki de Diego, Katerina Dörner, Tian Geng, Chan Kim, Faisal H.M. Koua, Diogo V.M. Melo, Mathieu Rappas, Adam Round, Ekaterina Round, Marcin Sikorski, Joana Valerio, Tiankun Zhou, Kristina Lorenzen, and Joachim Schulz J. Appl. Cryst. 56, 1038–1045 (2023) [BibTeX][pdf][abstract]doi:10.1107/S1600576723004405
35	Heterologous expression, purification and structural features of native Dictyostelium discoideum dye-decolorizing peroxidase bound to a natively incorporated heme Özlem Kalkan, Sravya Kantamneni, Lea Brings, Huijong Han, Richard Bean, Adrian P. Mancuso, and Faisal H.M. Koua Front. Chem. 11, 1220543 (2023) [BibTeX][pdf][abstract]doi:10.3389/fchem.2023.1220543
34	XFEL Microcrystallography of Self-Assembling Silver n-Alkanethiolates Mariya Aleksich, Daniel W. Paley, Elyse A. Schriber, Will Linthicum, Vanessa Oklejas, David W. Mittan-Moreau, Ryan P. Kelly, Patience A. Kotei, Anita Ghodsi, Raymond G. Sierra, Andrew Aquila, Frédéric Poitevin, Johannes P. Blaschke, Mohammad Vakili, Christopher J. Milne, Fabio Dall'Antonia, Dmitry Khakhulin, Fernando Ardana-Lamas, Frederico Lima, Joana Valerio, Huijong Han, Tamires Gallo, Hazem Yousef, Oleksii Turkot, Ivette Bermudez J. Macias, Thomas Kluyver, Philipp Schmidt, Luca Gelisio, Adam R. Round, Yifeng Jiang, Doriana Vinci, Yohei Uemura, Marco Kloos, Mark Hunter, Adrian P. Mancuso, Bryan D. Huey, Lucas R. Parent, Nicholas K. Sauter, Aaron S. Brewster, and Nathan J. Hohman J. Am. Chem. Soc. 145, 17042–17055 (2023) [BibTeX][abstract]doi:10.1021/jacs.3c02183
33	Experimental capabilities for liquid jet samples at sub-MHz rates at the FXE Instrument at European XFEL F. A. Lima, F. Otte, M. Vakili, F. Ardana-Lamas, M. Biednov, F. Dall'Antonia, P. Frankenberger, W. Gawelda, L. Gelisio, Huijong Han, X. Huang, Y. Jiang, M. Kloos, T. Kluyver, M. Knoll, K. Kubicek, Bermudez I.J. Macias, J. Schulz, O. Turkot, Y. Uemura, J. Valerio, H. Wang, H. Yousef, P. Zalden, D. Khakhulin, C. Bressler, and C. Milne J. Synchrotron Radiat. 30, 1168–1182 (2023) [BibTeX][pdf][abstract]doi:10.1107/S1600577523008159
32	First operation of the JUNGFRAU detector in 16-memory cell mode at European XFEL Marcin Sikorski, Marco Ramilli, Raphael de Wijn, Viktoria Hinger, Aldo Mozzanica, Bernd Schmitt, Huijong Han, Richard Bean, Johan Bielecki, Gábor Bortel, Thomas Dietze, Gyula Faigel, Konstantin Kharitonov, Chan Kim, Jayanath C.P. Koliyadu, Faisal H.M. Koua, Romain Letrun, Luis M. Lopez, Nadja Reimers, Adam Round, Abhisakh Sarma, Tokushi Sato, Miklós Tegze, and Monica Turcato Front. Phys. 11, 1303247 (2023) [BibTeX][pdf][abstract]doi:10.3389/fphy.2023.1303247
2022
31	Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y.A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H.M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, and Christian Betzel Commun. Biol. 5, 805 (2022) [BibTeX][pdf][abstract]doi:10.1038/s42003-022-03737-7
30	Hydrazones and thiosemicarbazones targeting protein-protein-interactions of SARS-CoV-2 papain-like protease Wiebke Ewert, Sebastian Günther, Francesca Miglioli, Sven Falke, Patrick Y.A. Reinke, Stephan Niebling, Christian Günther, Huijong Han, Vasundara Srinivasan, Hévila Brognaro, Julia Lieske, Kristina Lorenzen, Maria M. Garcia-Alai, Christian Betzel, Mauro Carcelli, Winfried Hinrichs, Dominga Rogolino, and Alke Meents Front. Chem. 10, 832431 (2022) [BibTeX][pdf][abstract]doi:10.3389/fchem.2022.832431
29	3D printed devices and infrastructure for liquid sample delivery at the European XFEL Mohammad Vakili, Johan Bielecki, Juraj Knoška, Florian Otte, Huijong Han, Marco Kloos, Robin Schubert, Elisa Delmas, Grant Mills, Raphael de Wijn, Romain Letrun, Simon Dold, Richard Bean, Adam Round, Yoonhee Kim, Frederico A. Lima, Katerina Dörner, Joana Valerio, Michael Heymann, Adrian P. Mancuso, and Joachim Schulz J. Synchrotron Radiat. 29, 331–346 (2022) [BibTeX][pdf][abstract]doi:10.1107/S1600577521013370
28	Electrically stimulated droplet injector for reduced sample consumption in serial crystallography Mukul Sonker, Diandra Doppler, Ana Egatz-Gomez, Sahba Zaare, Mohammad T. Rabbani, Abhik Manna, Jorvani Cruz Villarreal, Garrett Nelson, Gihan K. Ketawala, Konstantinos Karpos, Roberto C. Alvarez, Reza Nazari, Darren Thifault, Rebecca Jernigan, Dominik Oberthür, Huijong Han, Raymond Sierra, Mark S. Hunter, Alexander Batyuk, Christopher J. Kupitz, Robert E. Sublett, Frederic Poitevin, Stella Lisova, Valerio Mariani, Alexandra Tolstikova, Sebastien Boutet, Marc Messerschmidt, Domingo J. Meza-Aguilar, Raimund Fromme, Jose M. Martin-Garcia, Sabine Botha, Petra Fromme, Thomas D. Grant, Richard A. Kirian, and Alexandra Ros Biophys. Rep. 2, 100081 (2022) [BibTeX][pdf][abstract]doi:10.1016/j.bpr.2022.100081
2019–2021
27	X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease Sebastian Günther, Patrick Y.A. Reinke, Yaiza Fernández-García, Julia Lieske, Thomas J. Lane, Helen Ginn, Faisal H.M. Koua, Christiane Ehrt, Wiebke Ewert, Dominik Oberthuer, Oleksandr Yefanov, Susanne Meier, Kristina Lorenzen, Boris Krichel, Janine-Denise Kopicki, Luca Gelisio, Wolfgang Brehm, Ilona Dunkel, Brandon Seychell, Henry Gieseler, Brenna Norton-Baker, Beatriz Escudero-Pérez, Martin Domaracky, Sofiane Saouane, Alexandra Tolstikova, Thomas A. White, Anna Hänle, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, Miriam Barthelmess, Frank Schlünzen, Lourdu Xavier Paulraj, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Vasundara Srinivasan, Bruno Alves Franca, Martin Schwinzer, Hévila Brognaro, Cromarte Rogers, Diogo Melo, Jo J. Zaitsev-Doyle, Juraj Knoska, Gisel Peña E. Murillo, Aida Rahmani Mashhour, Filip Guicking, Vincent Hennicke, Pontus Fischer, Johanna Hakanpää, Jan Meyer, Phil Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Gleb Borenkov, David von Stetten, Guillaume Pompidor, Isabel Bento, Saravanan Panneerselvam, Ivars Karpics, Thomas R. Schneider, Maria Marta Garcia Alai, Stephan Niebling, Christian Günther, Christina Schmidt, Robin Schubert, Huijong Han, Juliane Boger, Diana C.F. Monteiro, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian G. Feiler, Manfred S. Weiss, Eike-Christian Schulz, Pedram Mehrabi, Katarina Karničar, Aleksandra Usenik, Jure Loboda, Henning Tidow, Ashwin Chari, Rolf Hilgenfeld, Charlotte Uetrecht, Russell Cox, Andrea Zaliani, Tobias Beck, Matthias Rarey, Stephan Günther, Dusan Turk, Winfried Hinrichs, Henry N. Chapman, Arwen R. Pearson, Christian Betzel, and Alke Meents Science 372, 642–646 (2021) [BibTeX][pdf][abstract]doi:10.1126/science.abf7945
26	The XBI BioLab for life science experiments at the European XFEL Huijong Han, Ekaterina Round, Robin Schubert, Yasmin Gül, Jana Makroczyová, Domingo Meza, Philipp Heuser, Martin Aepfelbacher, Imrich Barák, Christian Betzel, Petra Fromme, Inari Kursula, Poul Nissen, Elena Tereschenko, Joachim Schulz, Charlotte Uetrecht, Jozef Ulicný, Matthias Wilmanns, Janos Hajdu, Victor S. Lamzin, and Kristina Lorenzen J. Appl. Cryst. 54, 7–21 (2021) [BibTeX][pdf][abstract]doi:10.1107/S1600576720013989
25	Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease Sebastian Günther, Patrick Y.A. Reinke, Dominik Oberthuer, Oleksandr Yefanov, Helen Ginn, Susanne Meier, Thomas J. Lane, Kristina Lorenzen, Luca Gelisio, Wolfgang Brehm, Illona Dunkel, Martin Domaracky, Sofiane Saouane, Julia Lieske, Christiane Ehrt, Faisal Koua, Alexandra Tolstikova, Thomas A. White, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, Lourdu P. Xavier, Miriam Barthelmess, Frank Schlünzen, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Bruno Alves Franca, Martin Schwinzer, Hévila Brognaro, Brandon Seychell, Henry Gieseler, Diogo Melo, Jo J. Zaitsev-Doyle, Brenna Norton-Baker, Juraj Knoska, Gisel Esperanza, Aida Rahmani Mashhour, Filip Guicking, Vincent Hennicke, Pontus Fischer, Cromarte Rogers, Diana C.F. Monteiro, Johanna Hakanpää, Jan Meyer, Heshmat Noei, Phil Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian Feiler, Manfred Weiss, Eike-Christian Schulz, Pedram Mehrabi, Christina Schmidt, Robin Schubert, Huijong Han, Boris Krichel, Yaiza Fernández-García, Beatriz Escudero-Pérez, Stephan Günther, Dusan Turk, Charlotte Uetrecht, Tobias Beck, Henning Tidow, Ashwin Chari, Andrea Zaliani, Matthias Rarey, Russell Cox, Rolf Hilgenfeld, Henry N. Chapman, Arwen R. Pearson, Christian Betzel, and Alke Meents preprint (2020) [BibTeX][abstract]doi:10.1101/2020.05.02.043554
24	Molecular structure and function of myelin protein P0 in membrane stacking Arne Raasakka, Salla Ruskamo, Julia Kowal, Huijong Han, Anne Baumann, Anna Fasano Matti Myllykoski, Rocco Rossano, Paolo Riccio, Jochen Bürck, Anne S. Ulrich, Henning Stahlberg, and Petri Kursula Sci. Rep. 9, 642 (2019) [BibTeX][pdf][abstract]doi:10.1038/s41598-018-37009-4
23	Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation Esa-Pekka Kumpula, Andrea J. Lopez, Leila Tajedin, Huijong Han, and Inari Kursula PLoS Biol. 17, e3000315 (2019) [BibTeX][pdf][abstract]doi:10.1371/journal.pbio.3000315
2013–2017
22	Crystallographic anomalous diffraction data for the experimental phasing of two myelin proteins, gliomedin and periaxin Huijong Han and Petri Kursula Data in Brief 11, 552–556 (2017) [BibTeX][pdf][abstract]doi:10.1016/j.dib.2017.02.049
21	An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion Damien Jacot, Nicolò Tosetti, Isa Pires, Jessica Stock, Arnault Graindorge, Yu-Fu Hung, Huijong Han, Rita Tewari, Inari Kursula, and Dominique Soldati-Favre Cell Host Microbe 20, 731–743 (2016) [BibTeX][abstract]doi:10.1016/j.chom.2016.10.020
20	The Olfactomedin Domain from Gliomedin is a β-Propeller with Unique Structural Properties Huijong Han and Petri Kursula J. Biol. Chem. 290, 3612–3621 (2015) [BibTeX][pdf][abstract]doi:10.1074/jbc.M114.627547
19	Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping Huijong Han and Petri Kursula J. Biol. Chem. 289, 14121–14131 (2014) [BibTeX][pdf][abstract]doi:10.1074/jbc.M114.554816
18	Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin Huijong Han and Petri Kursula Acta Cryst. F 70, 1536–1539 (2014) [BibTeX][pdf][abstract]doi:10.1107/S2053230X14020305
17	Myelin-specific proteins: a structurally diverse group of membrane-interacting molecules Huijong Han, Matti Myllykoski, Salla Ruskamo, Chaozhan Wang, and Petri Kursula BioFactors 39, 233–241 (2013) [BibTeX][abstract]doi:10.1002/biof.1076
16	Preliminary crystallographic analysis of the N-terminal PDZ-like domain of periaxin, an abundant peripheral nerve protein linked to human neuropathies Huijong Han and Petri Kursula Acta Cryst. F 69, 804–808 (2013) [BibTeX][pdf][abstract]doi:10.1107/S1744309113016266
15	Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases Ernst Schonbrunn, Stephane Betzi, Riazul Alam, Martin P. Martin, Andreas Becker, Huijong Han, Rawle Francis, Ramappa Chakrasali, Sudhakar R. Jakkaraj, Aslamuzzaman Kazi, Said M. Sebti, Christopher L. Cubitt, Anthony W. Gebhard, Lori Hazlehurst, Joseph Sherwin Tash, and Gunda I. Georg J. Med. Chem. 56, 3768–3782 (2013) [BibTeX][abstract]doi:10.1021/jm301234k
14	Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family Matti Myllykoski, Arne Raasakka, Mari Lehtimäki, Huijong Han, Inari Kursula, and Petri Kursula J. Mol. Biol. 425, 4307–4322 (2013) [BibTeX][abstract]doi:10.1016/j.jmb.2013.06.012
2007–2012
13	Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: Active-site ligand binding and molecular conformation Matti Myllykoski, Arne Raasakka, Huijong Han, and Petri Kursula PLoS ONE 7, e32336 (2012) [BibTeX][pdf][abstract]doi:10.1371/journal.pone.0032336
12	Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) Jin-Yi Zhu, Yan Yang, Huijong Han, Stephane Betzi, Sanne H. Olesen, Frank Marsilio, and Ernst Schönbrunn J. Biol. Chem. 287, 12657–12667 (2012) [BibTeX][pdf][abstract]doi:10.1074/jbc.M112.342725
11	Discovery of a potential allosteric ligand binding site in CDK2 Stephane Betzi, Riazul Alam, Mathew Martin, Donna J. Lubbers, Huijong Han, Sudhakar R. Jakkaraj, Gunda I. Georg, and Ernst Schönbrunn ACS Chem. Biol. 6, 492–501 (2011) [BibTeX][abstract]doi:10.1021/cb100410m
10	The Fungal Product Terreic Acid is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) Huijong Han, Yan Yang, Sanne H. Olesen, Andreas Becker, Stephane Betzi, and Ernst Schönbrunn Biochemistry 49, 4276–4282 (2010) [BibTeX][abstract]doi:10.1021/bi100365b
9	Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr⁹⁷ → Ile and Pro¹⁰¹ → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli Todd Funke, Yan Yang, Huijong Han, Martha Healy-Fried, Sanne Olesen, Andreas Becker, and Ernst Schönbrunn J. Biol. Chem. 284, 9854–9860 (2009) [BibTeX][pdf][abstract]doi:10.1074/jbc.M809771200
8	X-ray Crystallographic and Solution State Nuclear Magnetic Resonance Spectroscopic Investigations of NADP⁺ Binding to Ferredoxin NADP Reductase from Pseudomonas aeruginosa An Wang, Juan Carlos Rodríguez, Huijong Han, Ernst Schönbrunn, and Mario Rivera Biochemistry 47, 8080–8093 (2008) [BibTeX][abstract]doi:10.1021/bi8007356
7	Differential Inhibition of Class I and Class II 5-Enolpyruvylshikimate-3-phosphate Synthases by Tetrahedral Reaction Intermediate Analogues Todd Funke, Martha L. Healy-Fried, Huijong Han, David G. Alberg, Paul A. Bartlett, and Ernst Schönbrunn Biochemistry 46, 13344–13351 (2007) [BibTeX][abstract]doi:10.1021/bi701095u
6	Biochemical and Structural Characterization of Pseudomonas aeruginosa Bfd and FPR: Ferredoxin NADP⁺ Reductase and not Ferredoxin is the Redox Partrner of Heme Oxygenase under Iron-Starvation Conditions An Wang, Yuhong Zeng, Huijong Han, Saroja Weeratunga, Bailey N. Morgan, Pierre Moënne-Loccoz, Ernst Schönbrunn, and Mario Rivera Biochemistry 46, 12198–12211 (2007) [BibTeX][abstract]doi:10.1021/bi7013135
5	Structural Basis of Glyphosate Tolerance Resulting from Mutations of Pro¹⁰¹ in Escherichia coli 5-Enolpyruvylshikimate-3-phosphate Synthase Martha L. Healy-Fried, Todd Funke, Melanie A. Priestman, Huijong Han, and Ernst Schönbrunn J. Biol. Chem. 282, 32949–32955 (2007) [BibTeX][pdf][abstract]doi:10.1074/jbc.M705624200
2005–2006
4	Molecular basis for the herbicide resistance of Roundup Ready crops Todd Funke, Huijong Han, Martha L. Healy-Fried, Markus Fischer, and Ernst Schönbrunn Proc. Natl. Acad. Sci. U. S. A. 103, 13010–13015 (2006) [BibTeX][pdf][abstract]doi:10.1073/pnas.0603638103
3	Synthesis of Mono- and Dihydroxylated Furanoses, Pyranoses, and an Oxepanose for the Preparation of Natural Product Analogue Libraries Xiao Ming Yu, Huijong Han, and Brian S.J. Blagg J. Org. Chem. 70, 5599–5605 (2005) [BibTeX][abstract]doi:10.1021/jo050558v
2000
2	Synthesis and NMR Studies of the RNA-Cleaving DNA Enzyme Yun-Jeong Choi, Hui-Jong Han, Joon-Hwa Lee, Se-Won Suh, and Byong-Seok Choi Bull. Korean Chem. Soc. 21, 955–956 (2000) [BibTeX][pdf][link]
1997
1	Conformational Study of Decamer DNA Duplex d(ACGTATACGT)₂ by NMR Spectroscopy Joon-Hwa Lee, Jin-Young Park, Hi-Jung Han, and Byong-Seok Choi J. Kor. Magn. Reson. Soc. 1, 63–70 (1997) [BibTeX][pdf][abstract][link]

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Han, Huijong, Ph.D.

All publications

Light-induced Trp_in/Met_out Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

Heterologous expression, purification and structural features of native Dictyostelium discoideum dye-decolorizing peroxidase bound to a natively incorporated heme

XFEL Microcrystallography of Self-Assembling Silver n-Alkanethiolates

Experimental capabilities for liquid jet samples at sub-MHz rates at the FXE Instrument at European XFEL

First operation of the JUNGFRAU detector in 16-memory cell mode at European XFEL

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

Hydrazones and thiosemicarbazones targeting protein-protein-interactions of SARS-CoV-2 papain-like protease

3D printed devices and infrastructure for liquid sample delivery at the European XFEL

Electrically stimulated droplet injector for reduced sample consumption in serial crystallography

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

The XBI BioLab for life science experiments at the European XFEL

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

Molecular structure and function of myelin protein P0 in membrane stacking

Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation

Crystallographic anomalous diffraction data for the experimental phasing of two myelin proteins, gliomedin and periaxin

An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion

The Olfactomedin Domain from Gliomedin is a β-Propeller with Unique Structural Properties

Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin

Myelin-specific proteins: a structurally diverse group of membrane-interacting molecules

Preliminary crystallographic analysis of the N-terminal PDZ-like domain of periaxin, an abundant peripheral nerve protein linked to human neuropathies

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases

Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family

Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: Active-site ligand binding and molecular conformation

Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)

Discovery of a potential allosteric ligand binding site in CDK2

The Fungal Product Terreic Acid is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)

Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr⁹⁷ → Ile and Pro¹⁰¹ → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli

X-ray Crystallographic and Solution State Nuclear Magnetic Resonance Spectroscopic Investigations of NADP⁺ Binding to Ferredoxin NADP Reductase from Pseudomonas aeruginosa

Differential Inhibition of Class I and Class II 5-Enolpyruvylshikimate-3-phosphate Synthases by Tetrahedral Reaction Intermediate Analogues

Biochemical and Structural Characterization of Pseudomonas aeruginosa Bfd and FPR: Ferredoxin NADP⁺ Reductase and not Ferredoxin is the Redox Partrner of Heme Oxygenase under Iron-Starvation Conditions

Structural Basis of Glyphosate Tolerance Resulting from Mutations of Pro¹⁰¹ in Escherichia coli 5-Enolpyruvylshikimate-3-phosphate Synthase

Molecular basis for the herbicide resistance of Roundup Ready crops

Synthesis of Mono- and Dihydroxylated Furanoses, Pyranoses, and an Oxepanose for the Preparation of Natural Product Analogue Libraries

Synthesis and NMR Studies of the RNA-Cleaving DNA Enzyme

Conformational Study of Decamer DNA Duplex d(ACGTATACGT)₂ by NMR Spectroscopy