Conformational Study of Decamer DNA Duplex d(ACGTATACGT)₂ by NMR Spectroscopy

Joon-Hwa Lee, Jin-Young Park, Hi-Jung Han, and Byong-Seok Choi

[BibTeX][pdf]http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JGGMB2_1997_v1n2_63

The conformation of the self-complementary decamer duplex, d(ACGTATACGT)₂ (TATA-duplex) has been studied dy proton NMR spectroscopy. The duplex is essentially B-type, with distortions apparent at the TATA steps. These conformational distortion which may be preferable to occur in the thymine residue on the 5'-side, has been investigated by unusual NOE crosspeaks.

Tags: NMR, DNA, KAIST